Description: This article from the HAPO Follow-Up Study examines how maternal insulin levels during pregnancy, measured by C-peptide, are associated with offspring metabolic health, including insulin sensitivity and beta-cell function, at ages 10–14. It highlights the potential role of maternal gestational insulin in shaping long-term risk for diabetes and metabolic disorders in children.

Citation: Rajamoorthi, A., Zheng, H., Skowronski, A. A., Zork, N., Reddy, U. M., Tung, P. W., Kupsco, A., Gallagher, D., Salem, R. M., Leibel, R. L., LeDuc, C. A., & Thaker, V. V. (2025). Association of gestational and childhood circulating C-peptide concentrations in the hyperglycemia and adverse pregnancy outcomes follow-up study. Diabetes research and clinical practice, 220, 111967. https://doi.org/10.1016/j.diabres.2024.111967