Description: This paper examines associations between diabetes distress/depressive symptoms and medication adherence in GRADE, a large randomized controlled trial comparing four glucose-lowering medications added to metformin in adults with relatively recent-onset type 2 diabetes mellitus (T2DM).

Citation: Hoogendoorn, C. J., Krause-Steinrauf, H., Uschner, D., Wen, H., Presley, C. A., Legowski, E. A., Naik, A. D., Golden, S. H., Arends, V. L., Brown-Friday, J., Krakoff, J. A., Suratt, C. E., Waltje, A. H., Cherrington, A. L., Gonzalez, J. S., & GRADE Research Group (2024). Emotional Distress Predicts Reduced Type 2 Diabetes Treatment Adherence in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE). Diabetes care, 47(4), 629–637. https://doi.org/10.2337/dc23-1401