Description: This publication is a secondary analysis of the GRADE trial, which compared four add-on diabetes treatments to metformin in people with relatively early type 2 diabetes. Over about 5 years, nearly one-third of participants were hospitalized at least once, and overall hospitalization rates were broadly similar across treatment groups.

Citation: Hsia, D. S., Younes, N., Ghosh, A., Kazemi, E. J., Krause-Steinrauf, H., Buse, J. B., Baker, C., Brown-Friday, J., Diaz, E., Diner, J., Groessl, E. J., Legowski, E. A., Mariash, C. N., Waltje, A. H., Wexler, D. J., Martin, C. L., & GRADE Research Group (2025). Association of Hospitalizations With Randomized Glycemia-Lowering Treatment in GRADE. Diabetes care, 48(7), 1288–1294. https://doi.org/10.2337/dc24-2839Hsia, D. S., Younes, N., Ghosh, A., Kazemi, E. J., Krause-Steinrauf, H., Buse, J. B., Baker, C., Brown-Friday, J., Diaz, E., Diner, J., Groessl, E. J., Legowski, E. A., Mariash, C. N., Waltje, A. H., Wexler, D. J., Martin, C. L., & GRADE Research Group (2025). Association of Hospitalizations With Randomized Glycemia-Lowering Treatment in GRADE. Diabetes care, 48(7), 1288–1294. https://doi.org/10.2337/dc24-2839