Description: This publication examines the role of advanced glycation end products (AGEs) in the development of diabetes-related complications. It explores how chronic hyperglycemia leads to AGE formation and how AGEs contribute to tissue damage, inflammation, and vascular dysfunction.

Citation: Schmidt, A. M., Hori, O., Chen, J. X., Li, J. F., Crandall, J., Zhang, J., Cao, R., Yan, S. D., Brett, J., & Stern, D. (1995). Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes. The Journal of clinical investigation, 96(3), 1395–1403. https://doi.org/10.1172/JCI118175